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phenobarbital will lower the level or influence of diazepam buccal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe. Powerful or average CYP3A4 inducers might enhance level of diazepam elimination; thus, efficacy of diazepam can be reduced.This mechanism might be with the induction of hepatic microsomal enzymes that met

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